Job Advertisement HKI-10/2021

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (Leibniz-HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The department of Molecular and Applied Microbiology invites talented and highly gifted candidates to apply for a position as

student assistant (f/div/m)

Topic: Fungal siderophore uptake

Siderophores are small molecules with a high ability to bind iron and are excreted by fungi to capture this essential nutrient in the environment. Furthermore, they were also shown to play an important role during the infection of humans with pathogenic fungi. The uptake of the iron-loaded forms by siderophore-transporters is thought to act as a proton symport. Nevertheless, it is also discussed that siderophore-transporters may act as receptors triggering endocytic uptake of these compounds. Therefore, the project deals with the investigation of the uptake mechanism of siderophores by siderophore-transporters in the important human pathogenic mould Aspergillus fumigatus.

The main topics are:

1. Genetic modification and fluorescent tagging of siderophore-transporters and lipid raft markers in A. fumigatus

2. Investigation of the uptake mechanism by live cell imaging
 

We offer:

A student assistant position for project-related work combined with general lab work. Applicants should be interested in microbial infection biology, molecular biology, practical lab experience as well as theoretical knowledge in microbiology, molecular biology and/or biochemistry (preferably late Bachelor or early Master stage students of Biology, Biochemistry, Microbiology or Molecular Medicine). We also expect excellent abilities to work in an international team. The work will be done on an hourly basis in a very well-equipped S2 laboratory. Initially we assume an hourly volume of 15h per week for 6 weeks.

As an equal opportunity employer the Leibniz-HKI is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

For further information:

Dr. Thomas Orasch | +49 3641 532 1307 | career@leibniz-hki.de

Applications:

Please apply by sending your application with CV and certificate of study/transcript of records, via the Leibniz-HKI online application system.