Job Advertisement HKI-03/2021

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (Leibniz-HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The Junior Research Group Biobricks of Microbial Natural Product Syntheses invites talented and highly gifted candidates to apply as a

Doctoral Researcher (f/div/m) in Fungal Synthetic Biology

for three years initially with the intention to obtain the doctoral degree.

Research Areas: Synthetic Biology, Molecular and Functional Genetics Compartmentalization of Secondary Metabolites

Project background:

Fungal secondary metabolites (SMs) play a considerable role in mediating microbial interaction in the environment. They are produced to improve fungal fitness and many different SMs are extracellularly secreted to act as scavengers, protectants, or even weapons against potential competitors; that’s why they are considered as a treasure trove for new active molecules. It has been already reported that some enzymes involved in secondary metabolism are compartmentalized in fungal vesicles, including proteins involved in the biosynthesis of antibiotics and mycotoxins. This implies that fungal SMs are highly regulated not only transcriptionally and translationally but also concerning their localization inside fungal cells. The aim of this project is to deeply understand mechanisms behind the organization and differentiation of organelles hosting SM biosynthetic pathways.

Candidate´s profile:

  • Master´s degree (or equivalent) in biology, chemistry, biochemistry or a related discipline
  • Strong interest in synthetic biology
  • Experience in molecular biology and/or chemical biology
  • Ability to perform team-oriented as well as independent work
  • Good communication skills in English are a must

We offer:

The successful candidate will be hosted in the Junior Research Group Biobricks of Microbial Natural Product Syntheses of Dr. Vito Valiante. The Leibniz-HKI is embedded in the outstanding scientific environment of the Beutenberg Campus providing state-of-the-art research facilities and a highly integrative network of life science groups. We offer multifaceted scientific projects with excellent technical facilities, a place in a dynamic, committed team, as well as strong scientific collaborations. The PhD candidate will participate in the structured program of the International Leibniz Research School and become an associated member of the Jena School of Microbial Communication.

Salary is paid according to German TV-L (salary agreement for public service employees). As an equal opportunity employer the Leibniz-HKI is committed to increase the percentage of female scientists and therefore especially encourages them to apply.
 

For further information:

Dr. Vito Valiante | +49 3641 532 1090 | career@leibniz-hki.de

Applications:

Complete applications in English or German should include a letter of interest, curriculum vitae, a complete list of publications, brief statement of research experiences, a list of three potential references, full academic record (copies of degree certificates), and should be submitted by February 28, 2021, via the online application system.