Job Advertisement HKI-23/2018

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The Department of Infection Biology invites talented and highly gifted candidates to apply for a

Doctoral Researcher (m/f) Infection Biology

Successful candidates will investigate the field Complement Evasion of pathogenic microbes including Candida albicans and Streptococcus pneumoniae. Main topics of the project are

  • Characterisation of pneumococcal, fungal and cellular immune evasion proteins
  • How do microbial proteins influence innate and cellular immune response?        
  • Functional characterization of FHR5 recruitment by pathogenic microbes

For further details please see literature below:

Requirement: Master degree in biology, genetics or life sciences. Experience, knowledge and good experimental skills in cell and molecular biology, genetics and biochemistry are of advantage.

For further information

Please contact Prof. Dr. Peter Zipfel | +49 3641 532 1300 | career@leibniz-hki.de

Applications

Salary is paid according to German TV-L (salary agreement for public service employees). As an equal opportunity employer the HKI is committed to increase the percentage of female scientists and therefore especially encourages them to apply.

Complete applications in English should include a letter of interest, curriculum vitae, a complete list of publications, brief statement of research experiences, a list of three potential references, full academic record (copies of degree certificates), and should be submitted by December 15, 2018 via the online application system.

Literature

Meinel C et al. (2017) Streptococcus pneumoniae from HUS patients bind human plasminogen via the surface protein PspC and use plasmin to damage human endothelial cells. J Inf Dis 21, 358-370.
 
Zipfel PF, Hallström T, Riesbeck K (2013) Pathogenic microbes - Tipping the balance. Mol Immunol 56:152-160.
 
Hallström T, Siegel C, Mörgelin M, Kraiczy P, Skerka C, Zipfel PF (2013) CspA from Borrelia burgdorferi inhibits the terminal complement pathway. mBio 4, pii: e00481-13. doi: 10.1128/mBio.00481-13.
 
Luo S, Hoffmann R, Skerka S, Zipfel PF (2013) Glycerol-3-phosphate Dehydrogenase 2 Is a Novel Factor H, FHL-1 and Plasminogen Binding Surface Protein of Candida albicans. J Infect Dis 207: 594-603.
 
Zipfel PF, Skerka C (2009) Complement regulators and inhibitory proteins. Nat Rev Immunol 9, 729-740.

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