Job Advertisement HKI-25/2018

The Leibniz Institute for Natural Product Research and Infection Biology – Hans Knöll Institute – (Leibniz-HKI, www.leibniz-hki.de) investigates the pathobiology of human-pathogenic fungi and identifies targets for the development of novel natural product-based antibiotics. The Department of Microbial Pathogenicity Mechanisms invites applications for one

Doctoral Researcher (f/m) (FungiNet)

in the field of Microbiology / Infection Biology / Cellular Microbiology.

The project will be co-financed by the Deutsche Forschungsgemeinschaft (DFG) and related to the CRC/TR 124 – FungiNet – Pathogenic fungi and their human host: Networks of interaction (see project C1 in: www.funginet.de).

Project background – Fungi infect billions of people annually, kill as many people as tuberculosis or malaria and are a major problem for healthcare. Candida albicans is a major opportunistic fungal pathogen and frequently causes superficial or even fatal infections. However, most humans are asymptotically colonised by this fungus as a part of their commensal microbiota. We are a leading research group in the investigation of Candida spp. pathogenicity mechanisms including their interaction with immune cells, their nutrient acquisition strategies, their evolution and adaptation in pathogenicity, the mechanisms involved in the commensal-to-pathogen shift and their capacity to cause host damage (see: www.leibniz-hki.de/en/mpm).

In this project, the successful applicant will use our sophisticated in vitro and ex vivo model systems to investigate important aspects of C. albicans' interaction networks during commensalism and pathogenesis, focussing on the direct interaction of C. albicans with host epithelial cells. The overarching goal is to elucidate the pathogenicity mechanisms which lead to host damage.

Candidate’s profile – We expect a Master´s degree (or equivalent) in Life Sciences (e.g. Biology, Biochemistry, or Microbiology). Furthermore, the applicant should be able to perform team-oriented as well as independent work. Practical experiences in one or more of the following subjects are beneficial: Microbiology, Molecular Biology, Infection Biology, Cell Biology. Practical experience in cell culture, microarrays or fungal genetics is an advantage.

We offer a doctoral researcher position for at least three years. The successful candidate will be hosted at the Department of Microbial Pathogenicity Mechanisms (MPM) at the Leibniz-HKI. The institute is embedded in the outstanding scientific environment of the Beutenberg Campus providing state-of-art research facilities and a highly integrative network of life science groups. We further offer a multifaceted scientific project with excellent technical facilities, a place in a young, committed team, as well as strong scientific collaborations. Furthermore, the successful candidate will be integrated into one of our graduate schools: ILRS (www.ilrs.de) or JSMC (www.jsmc.uni-jena.de) and will take part in the extensive local training programmes.

Salary is paid according to German TV-L (salary agreement for public service employees). HKI is an equal opportunity employer.

For further information:

Please contact Prof. Bernhard Hube | +49 3641 532 1401 | career@leibniz-hki.de

Applications

Complete applications in English should include a CV, a complete list of publications, a brief statement of research experiences, the addresses of two possible referees, and should be submitted by 31.12.2018 via the online application system of the HKI.


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